I am a woman aged 45. My knees heart me with every step. I have tried everything. Is there anything new?

Pain in my knees while sitting, becomes aggrevated when I stand up and while walking. Medications from Chondroitin-Glucosamine (Bla Bla) up to some, but slowly disappearing aid with NSAIDS with no success. Taping, Phys etc - nothing. Can I be helped? My Othop. Surgeon supposed Patellectomy but I cannot stay a long time with POP. Can anyone help?